Which glomerulonephritis is associated with an increased risk of venous thromboembolism?

Which glomerulonephritis is associated with an increased risk of venous thromboembolism?

• A. Membranous GN
• B. Minimal change disease
• C. FSGS
• D. IgA nephropathy

Answer: (A)

Nephrotic syndrome creates a hypercoagulable state because the kidneys lose substantial amounts of anticoagulant proteins like antithrombin III in the urine, while the liver increases production of clotting factors. Among glomerular diseases, membranous nephropathy classically presents with heavy proteinuria and hypoalbuminemia, making it the glomerulopathy most strongly associated with venous thromboembolism, including renal vein thrombosis. While other nephrotic diseases can also cause VTE, membranous nephropathy has the highest link due to the typical severity of proteinuria and the resultant hypercoagulable milieu.

Nephrotic syndrome creates a hypercoagulable state because the kidneys lose substantial amounts of anticoagulant proteins like antithrombin III in the urine, while the liver increases production of clotting factors. Among glomerular diseases, membranous nephropathy classically presents with heavy proteinuria and hypoalbuminemia, making it the glomerulopathy most strongly associated with venous thromboembolism, including renal vein thrombosis. While other nephrotic diseases can also cause VTE, membranous nephropathy has the highest link due to the typical severity of proteinuria and the resultant hypercoagulable milieu.